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Locasale, 2013)

In Phase 2 detoxification, various enzymes act directly on the toxic substances partially degraded and processed in Phase 1, such as heavy metals and organo-toxins, by binding them with protective compounds, thereby either inactivating the toxins

Together, these findings suggest that ROS within the TME both directly enhance T cell anti-tumor immunity and cooperate with intratumoral immune cells to drive tumor cell killing